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Updated: August 2020

It must be borne in mind that pain in diseases of internal organs may not occur for a long time and grow like an avalanche only during the incurable stage of the process (for example, with malignant neoplasms). After the cure of the somatic disease, persistent pain sensations are possible associated with the consequences of damage to the nerve trunks, their ischemic changes, the adhesions, changes in the functional state of the nodes of the preganglionic autonomic innervation, as well as with the psychogenic fixation of pain experience.

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